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KMID : 1024720220120010006
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Geriatric Rehabilitation
2022 Volume.12 No. 1 p.6 ~ p.20
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Clinical Rationale for Anti-aging Treatment
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Park Jeong-Hyun
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Abstract
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Aging is a biological process driven by the many numbers of biological and genetic pathways, which are closely related to lifespan, and are a very strong risk factor for all age-related diseases. Human life expectancy has greatly increased, but this has not been accompanied by a similar increase in their healthspan. Aging is a driving factor of various age-related diseases, including neurodegenerative diseases, cardiovascular diseases, cancer, immune system disorders, and musculoskeletal disorders. Current advances in the preventive and therapeutic strategies for these age-related degenerative diseases are still incomplete, partially because of the aging process itself. Modification of aging process itself might have profound impact on the development and progression of age-related diseases. Researches to find out medications and strategies that improve the healthspan by targeting the aging itself have now become a very hot topic in the medical researches. In this review, the status of aging research and the efforts for the development of potential pharmacological interventions for the age-related diseases, such as metformin, rapamycin, resveratrol, senolytics, as well as caloric restriction, will be briefly summarized. The feasibility, side effects, and future potential of these treatments will be also discussed, which will provide a basis to develop novel anti-aging therapeutics for improving the healthspan and preventing aging-related diseases.
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KEYWORD
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Aging, SIAS (stress induced accelerated senescence), ASIAS (asynchronous SIAS), Degenerative disease, Treatment
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